Darbagen is indicated for the treatment of anemia caused by:
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Darbepoetin alfa is an erythropoiesis-stimulating protein produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cells. It is a 165-amino acid protein that differs from recombinant human erythropoietin by containing 5 N-linked oligosaccharide chains (compared to the 3 chains in recombinant human erythropoietin). These extra glycosylation sites are due to amino acid substitutions in the peptide backbone.
Correction phase: Initial dose is 0.45 µg/kg body weight, given subcutaneously or intravenously once a week. Alternative doses for patients not on dialysis: 0.75 µg/kg every two weeks or 1.5 µg/kg once a month.
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